SIBO (small intestine bacterial overgrowth) is a frequent cause of IBS. This idea was developed by Dr. Pimentel of Cedars-Sinai.
https://www.cedars-sinai.edu/Research/Research-Labs/Pimentel-Lab/
There is a hydrogen breath test that has been developed to determine whether a person has bacteria in the small intestine that produce hydrogen. Methane is often also tested.
However, I recently learned that if someone is negative on this test, that does not mean that they do not have SIBO! Apparently there are other bacteria that can be involved that don't produce hydrogen or methane. So just because a patient has a negative SIBO test, this does not mean that they do not have SIBO or IBS.
High blood B-12 levels and high folate levels are an indication that there is bacteria in the small intestine that are producing these vitamins, or at least B-12 analogues in the terminal ileum of the small intestine, according to Dr. William Sandborn and NP Elizabeth Evans, of UC San Diego Health System.
Dr. Sandborn also stated that Crohn's is a disease of dysbiosis, and that most Crohn's patients have SIBO.
Examining current ideas of treatments that can help improve Crohn's Disease.
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